GABAA Receptor Defects Can Cause Epilepsy
نویسندگان
چکیده
منابع مشابه
Epilepsy, E/I Balance and GABAA Receptor Plasticity
GABA(A) receptors mediate most of the fast inhibitory transmission in the CNS. They form heteromeric complexes assembled from a large family of subunit genes. The existence of multiple GABA(A) receptor subtypes differing in subunit composition, localization and functional properties underlies their role for fine-tuning of neuronal circuits and genesis of network oscillations. The differential r...
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The tonic activation of extrasynaptic GABAA receptors by extracellular GABA provides a powerful means of regulating neuronal excitability. A consistent finding from studies that have used various models of temporal lobe epilepsy is that tonic GABAA receptor-mediated conductances are largely preserved in epileptic brain (in contrast to synaptic inhibition which is often reduced). Tonic inhibitio...
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Temporal lobe epilepsy (TLE) associated with hippocampal sclerosis (HS) is a form of focal epilepsy, which is particularly resistant to medical treatment. It is, however, established that patients with TLE and HS respond favorably to surgery. Accumulating evidence indicates that TLE is associated with impairment in synaptic signaling via GABA (γ-aminobutyric acid), the main inhibitory neurotran...
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gamma-Aminobutyric acid (GABA)A receptors for the inhibitory neurotransmitter GABA are likely to be found on most, if not all, neurons in the brain and spinal cord. They appear to be the most complicated of the superfamily of ligand-gated ion channels in terms of the large number of receptor subtypes and also the variety of ligands that interact with specific sites on the receptors. There appea...
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We studied the effects of phosphorylation by protein kinase A (PKA) on GABAA receptors ( 1 1 2L and 1 3 2L) transiently expressed in HEK 293T cells. Under conditions favorable for PKA activation, currents obtained using whole-cell patch clamp of lifted cells displayed increased rate and extent of the fast phases of desensitization, decreased rate of current deactivation after GABA removal, and ...
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ژورنال
عنوان ژورنال: Epilepsy Currents
سال: 2001
ISSN: 1535-7597,1535-7511
DOI: 10.1046/j.1535-7597.2001.00018.x